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Zhengqian Li, Taotao Liu, Ning Yang, Dengyang Han, Xinning Mi, Yue Li, Kaixi Liu, Alain Vuylsteke, Hongbing Xiang, Xiangyang Guo
《医学前沿(英文)》 2020年 第14卷 第5期 页码 533-541 doi: 10.1007/s11684-020-0786-5
关键词: coronavirus disease 2019 (COVID-19) SARS-CoV-2 neurological manifestations neuroinvasion brain
Atypical manifestations of acute coronary syndrome — throat discomfort: a multi-center observational
《医学前沿(英文)》 2022年 第16卷 第4期 页码 651-658 doi: 10.1007/s11684-021-0859-0
关键词: acute coronary syndrome (ACS) throat discomfort (TD) throat pain cardiology departments non-cardiologic physicians
Clinical manifestations and outcomes in severe ulcerative colitis
YANG Xuesong, YAO Wei, LIU Wenbin, LI Jun, LU Yumin
《医学前沿(英文)》 2007年 第1卷 第2期 页码 192-195 doi: 10.1007/s11684-007-0036-0
The development and benefits of metformin in various diseases
《医学前沿(英文)》 2023年 第17卷 第3期 页码 388-431 doi: 10.1007/s11684-023-0998-6
关键词: metformin metabolism cancer aging neurological disorder
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《医学前沿(英文)》 2011年 第5卷 第1期 页码 86-93 doi: 10.1007/s11684-011-0118-x
Netrin-1 (NT-1) is one of the axon-guiding molecules that are critical for neuronal development. Because of its structural homology to the endothelial mitogens, NT-1 may have similar effects on vascular network formation. NT-1 was shown to be able to stimulate the proliferation and migration of human cerebral endothelial cells in vitro and also promote focal neovascularization in adult brain in vivo. In the present study, we reported the delivery of NT-1 using an adeno-associated virus (AAV) vector (AAV-NT-1) into mouse brain followed by transient middle cerebral artery occlusion (tMCAO). We found that AAV vectors did not elicit a detectable inflammatory response, cell loss or neuronal damage after brain transduction. The level of NT-1 was increased in the AAV-NT-1-transduced tMCAO mice compared with the control mice. Furthermore, the neurobehavioral outcomes were significantly improved in AAV-NT-1-transduced mice compared with the control animals (P<0.05) 7 days after tMCAO. Our data suggests that NT-1 plays a neuronal function recovery role in ischemic brain and that NT-1 gene transfer might present a valuable approach to treat brain ischemic disorders.
关键词: adeno-associated virus angiogenesis gene transfer ischemia middle cerebral artery occlusion netrin-1
Clinical manifestations and pathogen characteristics in children admitted for suspected COVID-19
Xiaofang Cai, Hanlan Jiang, Simin Zhang, Shengying Xia, Wenhui Du, Yaoling Ma, Tao Yu, Wenbin Li
《医学前沿(英文)》 2020年 第14卷 第6期 页码 776-785 doi: 10.1007/s11684-020-0820-7
关键词: coronavirus disease 2019 pediatrics emergency retrospective investigation severe acute respiratory syndrome coronavirus 2
肠道菌群是调节神经系统功能紊乱的潜在靶点 Review
武万强, 孔庆敏, 田培郡, 翟齐啸, 王刚, 刘小鸣, 赵建新, 张灏, Yuan Kun Lee, 陈卫
《工程(英文)》 2020年 第6卷 第4期 页码 415-423 doi: 10.1016/j.eng.2019.07.026
众所周知,肠道菌群在调节宿主生理功能方面具有重要作用,如调节免疫和代谢平衡。近年来,越来越多证据表明肠道菌群能够通过肠-脑轴调节中枢神经系统功能,这为研究肠道和大脑间的相互作用关系开辟了一条新路径。本文首先介绍了肠道菌群与大脑相互作用的肠–脑轴分子机制,以及肠道菌群失调引发的神经系统功能紊乱;然后介绍了调节肠道菌群失衡是干预神经系统功能紊乱的潜在策略,如益生菌、益生元、合生元以及饮食等干预措施。目前关于肠道菌群–肠–脑轴方面的研究尚处在起步阶段,但继续深入阐明肠道菌群调节神经系统功能的分子机制不仅能揭示神经系统功能紊乱的新型病理机制,而且能够为神经系统功能紊乱提供潜在的诊断标志物和干预策略。
Peter T. Cummings, Philippe M. Fauchet, Michael Goldfarb, Martha W.M. Jones, Maithilee Kunda, Jonathan B. Perlin, Nilanjan Sarkar, Keivan G. Stassun, Zachary E. Warren, Karl E. Zelik
《工程(英文)》 2021年 第7卷 第2期 页码 141-143 doi: 10.1016/j.eng.2020.06.020
标题 作者 时间 类型 操作
Neurological manifestations of patients with COVID-19: potential routes of SARS-CoV-2 neuroinvasion from
Zhengqian Li, Taotao Liu, Ning Yang, Dengyang Han, Xinning Mi, Yue Li, Kaixi Liu, Alain Vuylsteke, Hongbing Xiang, Xiangyang Guo
期刊论文
Atypical manifestations of acute coronary syndrome — throat discomfort: a multi-center observational
期刊论文
Clinical manifestations and outcomes in severe ulcerative colitis
YANG Xuesong, YAO Wei, LIU Wenbin, LI Jun, LU Yumin
期刊论文
Overexpression of netrin-1 improves neurological outcomes in mice following transient middle cerebral
null
期刊论文
Clinical manifestations and pathogen characteristics in children admitted for suspected COVID-19
Xiaofang Cai, Hanlan Jiang, Simin Zhang, Shengying Xia, Wenhui Du, Yaoling Ma, Tao Yu, Wenbin Li
期刊论文